Highlights
Point mutations of MmTMC1/2 are localized to the plasma membrane of heterologous cells
CRISPRi promotes HsTMC1/2 trafficking to the plasma membrane of heterologous cells
HsTMC1 and HsTMC2 can be activated by mechanical stimuli
HsTMC1 and HsTMC2 are pore-forming subunits of mechanogated ion channels
Title
Human TMC1 and TMC2 are mechanically gated ion channels
Authors
Songdi Fu, Xueqi Pan, Mingshun Lu, Jianying Dong, Zhiqiang Yan
Journal Information
Neuron (2024)
DOI
https://10.1016/j.neuron.2024.11.009
